IMO the type of floor makes all the difference.
My experience is with a suspended wood floor (13 x 18', thick wall-to-wall carpet) which I have braced from the basement below (2 x 12 foot 4x4s running below the floor joists, supported by 4 adjustable basement-column thingies, as well as other tweaks like silicone caulking of all joist/subfloor intersections).
This bracing has made a tremendous improvement in SQ and was great for the TT.
However I could still easily perceive that the bass from my spiked Von Schweickert VR4JRs was being "drilled into" the floor, resulting in peaky, inconsistent bass across those frequencies.
As I was thinking about ways to improve isolation I came across the Auralex Gramma platforms, which were very similar to what I was planning in my head. During a Rave I enlisted the help of youse guys to put the speaks up on the platforms and there was universal praise for the major SQ enhancement and I haven't thought of removing the platforms since.
Taking the floor (mostly? who knows how much...) out of the SQ equation was a major improvement for me in my system and I would highly recommend this product for isolation, WAF and speaker geometry permitting.
The changes wrought by worrying out my floor/speaker interaction were massive.
I'm jelly of you concrete slab guys...
-Mike