Changing tubes has made the biggest differences. Sometimes better, sometimes worse.... With my current amps, I like the stock tubes the best. I wish I knew that before trying so many other flavors. Nervosa got me on that one...
Yup the black Sands silver reference Mk V power cables made a nice improvement too. But they hate any filtering.
Herbies dampers on the splitter/gain tube also made a small but noticeable improvement, depending on how microphonic that tube is. Yeah, I swap that one a lot too. Stock is back in there now.
I would like to try some form of vibe isolation too, maybe Maple stands, and floor bracing.